LOGIN

International Epidemiology Databases to Evaluate AIDS

Home >> Publications >> Accelerated biological ageing in HIV-infected individuals in South Africa: a case-control study.

Publication

Author(s):

Pathai S, Lawn SD, Gilbert CE, McGuinness D, McGlynn L, Weiss HA, Port J, Christ T, Barclay K, Wood R, Bekker LG, Shiels PG.

Pub Title:

Accelerated biological ageing in HIV-infected individuals in South Africa: a case-control study.

Pub Date:

Sep 24 2013

Pub Region(s):

Southern Africa

Journal Issue:

27(25)

Page Number:
2375-2384

Journal:

Title: 
AIDS
Link: 
http://ovidsp.tx.ovid.com/sp-3.10.0b/ovidweb.cgi?QS2=434f4e1a73d37e8c8b3eab7e2fc8fd7c3c8eb6b4092c40069f26efbf87d7142a94c4ee01b6aaf311265ad8ba7b09630d4ce8b7eb48c6e5b0e4ced42a576c1694e35f45695e204af34584a6f7c9708ac8fea6f1e42be70af8d8a2da66442cb84857982c11e1

PubMed: 23751258
Pub PDF: PDF icon 23751258.pdf

Abstract
OBJECTIVES
: Little is known about the impact of HIV infection on biological ageing in sub-Saharan Africa. The study aimed to assess biological ageing in South African HIV-infected adults and HIV-seronegative individuals using two validated biomarkers, telomere length and CDKN2A expression (a mediator of cellular senescence).

DESIGN: A case-control study.

METHODS: Two hundred and thirty-six HIV-infected adults aged at least 30 years and 250 age and sex frequency matched HIV-seronegative individuals were recruited from clinics in township communities in Cape Town. Biological ageing was evaluated by measurement of telomere length and CDKN2A expression in peripheral blood leukocytes.

RESULTS: The median ages of the HIV-infected and HIV-seronegative participants were 39 and 40 years, respectively. Among HIV-infected participants, 87.1% were receiving antiretroviral therapy (ART), their median CD4⁺ cell count was 468 cells/μl and 84.3% had undetectable viral load. Both biomarkers were validated against chronological age in HIV-seronegative individuals. Telomere length was significantly shorter in HIV-infected individuals than in HIV-seronegative individuals (mean relative T/S ratio ±SE:0.91 ± 0.007 vs. 1.07 ± 0.008, P < 0.0001). CD2NKA expression was higher in HIV-infected participants than in HIV-seronegative individuals (mean expression: 0.45 ± 0.02 vs. 0.36 ± 0.03, P = 0.003). Socioeconomic factors were not associated with biological ageing in HIV-infected participants. However, in participants on ART with undetectable viral load, biomarker levels indicated greater biological ageing in those with lower current CD4⁺ cell counts.

CONCLUSION: Telomere length and CDKN2A expression were both consistent with increased biological ageing in HIV-infected individuals. Prospective studies of the impact of HIV on biological ageing in sub-Saharan Africa are warranted.

© 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins

PMID: 23751258 [PubMed - in process]

PMCID: PMC3805356

 

The following websites provide guidelines and policies when citing from PubMed®: http://www.ncbi.nlm.nih.gov/books/NBK7243/
http://www.nlm.nih.gov/bsd/policy/cit_format.html

Citation:

Pathai S, Lawn SD, Gilbert CE, McGuinness D, McGlynn L, Weiss HA, Port J, Christ T, Barclay K, Wood R, Bekker LG, Shiels PG. Accelerated biological ageing in HIV-infected individuals in South Africa: a case-control study. AIDS. 2013 Sep 24;27(15):2375-84. doi: 10.1097/QAD.0b013e328363bf7f. PubMed PMID: 23751258; PubMed Central PMCID: PMC3805356.