LOGIN

International Epidemiology Databases to Evaluate AIDS

Home >> Publications >> Age-specific and sex-specific weight gain norms to monitor antiretroviral therapy in children in low-income and middle-income countries.

Publication

Author(s):

Yotebieng M, Meyers T, Behets F, Davies MA, Keiser O, Ngonyani KZ, Lyamuya RE, Kariminia A, Hansudewechakul R, Leroy V, Koumakpai S, Newman J, Van Rie A.

Pub Title:

Age-specific and sex-specific weight gain norms to monitor antiretroviral therapy in children in low-income and middle-income countries.

Pub Date:

Jan 2 2015

Journal:

Title: 
AIDS
Link: 
http://ovidsp.tx.ovid.com/sp-3.14.0b/ovidweb.cgi?QS2=434f4e1a73d37e8c740ce3cde7a337859aa2a156d2b22d6b6ef2cb243c21d9615461ff1d0afc84b43b567e226dd7f216ee8dc13152d66e42775a298ce57358107bdd86f95c7ae18533493c7e7dc35b71edfca1a86e5fde2f9194628953793739c4c6ff5f16

PubMed: 25562494
Pub PDF: PDF icon 25562494.pdf

Abstract
BACKGROUND:
Viral load and CD4% are often not available in resource-limited settings for monitoring children's responses to antiretroviral therapy (ART). We aimed to construct normative curves for weight gain at 6, 12, 18, and 24 months following initiation of ART in children, and to assess the association between poor weight gain and subsequent responses to ART.

DESIGN: Analysis of data from HIV-infected children younger than 10 years old from African and Asian clinics participating in the International epidemiologic Databases to Evaluate AIDS.

METHODS: The generalized additive model for location, scale, and shape was used to construct normative percentile curves for weight gain at 6, 12, 18, and 24 months following ART initiation. Cox proportional models were used to assess the association between lower percentiles (< 50th) of weight gain distribution at the different time points and subsequent death, virological suppression, and virological failure.

RESULTS: Among 7173 children from five regions of the world, 45% were underweight at baseline. Weight gain below the 50th percentile at 6, 12, 18, and 24 months of ART was associated with increased risk of death, independent of baseline characteristics. Poor weight gain was not associated with increased hazards of virological suppression or virological failure.

CONCLUSION: Monitoring weight gain on ART using age-specific and sex-specific normative curves specifically developed for HIV-infected children on ART is a simple, rapid, sustainable tool that can aid in the identification of children who are at increased risk of death in the first year of ART.

The following websites provide guidelines and policies when citing from PubMed®: http://www.ncbi.nlm.nih.gov/books/NBK7243/
http://www.nlm.nih.gov/bsd/policy/cit_format.html

Citation:

Yotebieng M, Meyers T, Behets F, Davies MA, Keiser O, Ngonyani KZ, Lyamuya RE, Kariminia A, Hansudewechakul R, Leroy V, Koumakpai S, Newman J, Van Rie A. Age-specific and sex-specific weight gain norms to monitor antiretroviral therapy in children in low-income and middle-income countries. AIDS. 2015 Jan 2;29(1):101-9. doi: 10.1097/QAD.0000000000000506. PubMed PMID: 25562494.