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Home >> Publications >> Antiretroviral therapy outcomes of HIV-infected children in the TREAT Asia pediatric HIV observational database.

Publication

Author(s):

Hansudewechakul R, Sirisanthana V, Kurniati N, Puthanakit T, Lumbiganon P, Saphonn V, Yusoff NK, Kumarasamy N, Fong SM, Nallusamy R, Srasuebkul P, Law M, Sohn AH, Chokephaibulkit K; TREAT Asia Pediatric HIV Observational Database.

Pub Title:

Antiretroviral therapy outcomes of HIV-infected children in the TREAT Asia pediatric HIV observational database.

Pub Date:

Dec 31 2010

Pub Region(s):

Asia-Pacific

Journal Issue:

4

Page Number:
503-9

Journal:

Title: 
JAIDS- Journal of Acquired Immune Deficiency Syndromes
Link: 
http://journals.lww.com/jaids/pages/articleviewer.aspx?year=2010&issue=12010&article=00014&type=abstract

PubMed: 20842043
Pub PDF: PDF icon 20842043.pdf

Abstract
INTRODUCTION
: We report responses to combination antiretroviral therapy (cART) in the Therapeutics Research, Education, and AIDS Training in Asia Pediatric HIV Observational Database.

METHODS: Children included were those who had received cART (ie, ≥3 antiretrovirals) at <18 years. The analysis was intention-to-treat by the first cART regimen. Median values are provided with interquartile ranges; hazard ratios (HRs) with 95% confidence intervals.

RESULTS: Of the 1655 children included, 50.4% were male, with a median age at cART of 7.0 (3.9-9.8) years and CD4 of 8% (2.0%-15%); 92.5% were started on an NNRTI; median duration of follow-up was 2.9 (1.4-4.6) years. Loss-to-follow-up and death rates were 4.2 (3.7-4.8) and 2.1 (1.7-2.5) per 100 person-years, respectively. At 36 months, median CD4 was 26% (21%-31%); 81% of those with viral load (n = 302) were <400 copies per milliliter. Children who reached CD4 ≥25% within 5 years were more likely to be females (HR: 1.4; 1.2-1.7), start before 18 months old (HR: 3.8; 2.4-6.2), lack a history of monotherapy/dual therapy (HR: 1.7; 1.4-2.5), and have a higher baseline CD4 (per 10% increase: HR: 2; 1.9-2.2).

CONCLUSIONS: These data underscore the need for early diagnosis and cART initiation to preserve immune function.

PMID: 20842043 [PubMed - indexed for MEDLINE]

PMCID: PMC2975064

 

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Citation:

Hansudewechakul R, Sirisanthana V, Kurniati N, Puthanakit T, Lumbiganon P, Saphonn V, Yusoff NK, Kumarasamy N, Fong SM, Nallusamy R, Srasuebkul P, Law M, Sohn AH, Chokephaibulkit K; TREAT Asia Pediatric HIV Observational Database. Antiretroviral therapy outcomes of HIV-infected children in the TREAT Asia pediatric HIV observational database. J Acquir Immune Defic Syndr. 2010 Dec;55(4):503-9. doi: 10.1097/QAI.0b013e3181f5379a. PubMed PMID: 20842043; PubMed Central PMCID: PMC2975064.