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Home >> Publications >> Cervical human papillomavirus and HIV infection in women of child-bearing age in Abidjan, Côte d'Ivoire, 2010.

Publication

Author(s):

Jaquet A, Horo A, Charbonneau V, Ekouevi DK, Roncin L, Toure B, Coffie P, Minga A, Sasco AJ, Garrigue I, Fleury H, Dabis F; IeDEA West Africa collaboration.

Pub Title:

Cervical human papillomavirus and HIV infection in women of child-bearing age in Abidjan, Côte d'Ivoire, 2010.

Pub Date:

Jul 24 2012

Pub Region(s):

West Africa

Journal Issue:

3

Page Number:
556-63

Journal:

Title: 
British Journal Cancer
Link: 
http://www.nature.com/bjc/journal/v107/n3/full/bjc2012299a.html

PubMed: 22782349
Pub PDF: PDF icon 22782349.pdf

Abstract

BACKGROUND: We sought to document the association of Human immunodeficiency Virus (HIV) infection and immunodeficiency with oncogenic Human Papillomavirus (HPV) infection in women with no cervical neoplastic lesions identified through a cervical cancer screening programme in Côte d'Ivoire.

METHODS: A consecutive sample of women stratified on their HIV status and attending the national blood donor clinic or the closest HIV clinic was recruited during a cervical cancer screening programme based on the visual inspection. Diagnosis of HPV infection and genotype identification were based on the Linear Array; HPV test.

RESULTS: A total of 445 (254 HIV-positive and 191 HIV-negative) women were included. The prevalence of oncogenic HPV infection was 53.9% (95% confidence interval (CI) 47.9-59.9) in HIV-positive women and 33.7% (95% CI 27.1-40.3) in HIV-negative women (odds ratio (OR)=2.3 (95% CI 1.5-3.3)). In multivariate analysis, HIV-positive women with a CD4 count <200 cells mm(3) or between 200 and 499 cells mm(3) were more likely to harbour an oncogenic HPV compared with women with a CD4 count ≥500 cells mm(3) with OR of 2.8 (95% CI 1.1-8.1) and 1.7 (95% CI 1.0-2.9), respectively.

CONCLUSION: A high prevalence of oncogenic HPV was found in women with no cervical neoplastic lesions, especially in HIV-positive women. Despite antiretroviral use, immunodeficiency was a main determinant of the presence of oncogenic HPV.

© 2012 Cancer Research UK

PMID: 22782349 [PubMed - indexed for MEDLINE]

PMCID: PMC3405229

 

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Citation:

Jaquet A, Horo A, Charbonneau V, Ekouevi DK, Roncin L, Toure B, Coffie P, Minga A, Sasco AJ, Garrigue I, Fleury H, Dabis F; IeDEA West Africa collaboration. Cervical human papillomavirus and HIV infection in women of child-bearing age in Abidjan, Côte d'Ivoire, 2010. Br J Cancer. 2012 Jul 24;107(3):556-63. doi: 10.1038/bjc.2012.299. Epub 2012 Jul 10. PubMed PMID: 22782349; PubMed Central PMCID: PMC3405229.