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Home >> Publications >> Clostridium difficile in a HIV-Infected Cohort: Incidence, Risk Factors, and Clinical Outcomes.

Publication

Author(s):

Haines CF, Moore RD, Bartlett JG, Sears CL, Cosgrove SE, Carroll K, Gebo KA.

Pub Title:

Clostridium difficile in a HIV-Infected Cohort: Incidence, Risk Factors, and Clinical Outcomes.

Pub Date:

Nov 13 2013

Journal Issue:

27(17)

Page Number:
2799-2807

Journal:

Title: 
AIDS
Link: 
http://bit.ly/1fz58lo

PubMed: 23842125
Pub PDF: PDF icon 23842125.pdf

Abstract
OBJECTIVE
: C. difficile is the most commonly reported infectious diarrhea in HIV-infected patients in the United States. We set out to determine the incidence, risk factors, and clinical presentation of C. difficile infections (CDI) in a cohort of HIV-infected subjects.

DESIGN: We performed a nested, case-control analysis with four non-CDI controls randomly selected for each case.

METHODS: We assessed the incidence of CDI in the Johns Hopkins HIV Clinical Cohort between July 1, 2003 and December 31, 2010. Incident cases were defined as first positive C. difficile cytotoxin assay or PCR for toxin B gene. We used conditional logistic regression models to assess risk factors for CDI. We abstracted data on the clinical presentation and outcomes from case chart review.

RESULTS: We identified 154 incident CDI cases for an incidence of 8.3 cases/1000 patient years. No unique clinical features of HIV-associated CDI were identified. In multivariate analysis, risk of CDI was independently increased for: CD4 count ≤50 cells/mm (Adjusted Odds Ratio (AOR) 20.7, 95% CI 2.8-151.4), hospital onset CDI (AOR 26.7 [3.1-231.2]), and use of clindamycin (AOR 27.6 [2.2-339.4]), fluoroquinolones (AOR 4.5 [1.2-17.5]), macrolides (AOR 6.3 [1.8-22.1]), gastric acid suppressants (AOR 3.1 [1.4-6.9]), or immunosuppressive agents (AOR 6.8 [1.2-39.6]).

CONCLUSIONS: The incidence of CDI in HIV-infected patients was twice that previously reported. Our data show compromised cellular immunity, as defined by CD4 ≤50 cells/mm, is a risk factor for CDI. Clinicians should be aware of the increased CDI risk, particularly in those with severe CD4 count suppression.

PMID: 23842125 [PubMed - as supplied by publisher]

 

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Citation:

Haines CF, Moore RD, Bartlett JG, Sears CL, Cosgrove SE, Carroll K, Gebo KA. Clostridium difficile in a HIV-Infected Cohort: Incidence, Risk Factors, and Clinical Outcomes. AIDS. 2013 Jul 9. [Epub ahead of print] PubMed PMID: 23842125.