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Home >> Publications >> Echocardiography and carotid intima-media thickness among asymptomatic HIV-infected adolescents in Thailand.

Publication

Author(s):

Chanthong P, Lapphra K, Saihongthong S, Sricharoenchai S, Wittawatmongkol O, Phongsamart W, Rungmaitree S, Kongstan N, Chokephaibulkit K.

Pub Title:

Echocardiography and carotid intima-media thickness among asymptomatic HIV-infected adolescents in Thailand.

Pub Date:

Sep 10 2014

Pub Region(s):

Asia-Pacific

Journal:

Title: 
AIDS
Link: 
http://ovidsp.tx.ovid.com/sp-3.13.1a/ovidweb.cgi?QS2=434f4e1a73d37e8c8b3eab7e2fc8fd7c3c8eb6b4092c40066069ce59751f54742b8400c250c471abf3fe0b4609209768cfdb80f1eddfae347e76e6919161e22dfcf38a29e21f57199565fda8792e963c92c916c3caf56248f45e6a09cab516a6ba1fbbdd7f

PubMed: 25265075
Pub PDF: PDF icon 25265075.pdf

Abstract
OBJECTIVES:
To evaluate the carotid intima-media thickness (cIMT) in perinatally HIV-infected adolescents and factors associated with cardiovascular abnormalities.

DESIGNS: A cross-sectional study was conducted in perinatally HIV-infected adolescents who had no known cardiovascular condition and healthy controls.

METHODS: Transthoracic echocardiogram and cIMT measurements were taken by pediatric cardiologists. Serum lipid profiles, high-sensitivity C-reactive protein and N-terminal pro-brain natriuretic peptide were measured.

RESULTS: Hundred HIV-infected and 50 healthy adolescents were enrolled. Echocardiograms revealed overall normal systolic function (median left-ventricular ejection fraction 66 vs. 66%; P = 0.825). The mean overall cIMTs of common carotid arteries and internal carotid arteries were not different between the groups (0.373 vs. 0.371; P = 0.744). Among the HIV-infected adolescents, those who had been receiving protease inhibitor-containing regimens had an increased cIMT (0.364 vs. 0.381 mm; P = 0.009). Hypertriglyceridemia was found in 52% of those who had received protease inhibitors for more than 6 months, but only in 21% of those who had never received protease inhibitors (odds ratio 4.0, 95% confidence interval 1.6-9.7, P = 0.002). Current HIV-RNA, CD4, BMI, sex, cholesterol and low-density lipoprotein-cholesterol were not associated with increased cIMT. Serum high-sensitivity C-reactive protein and N-terminal pro-brain natriuretic peptide were not different between the groups and not associated with cardiac abnormalities.

CONCLUSIONS: Perinatally HIV-infected adolescents had comparable myocardial function and similar cIMT measurements to healthy adolescents. However, hypertriglyceridemia and increased cIMT were found in HIV-infected adolescents receiving protease inhibitor-based regimens. Longer-term follow-up is needed to evaluate HIV-associated cardiovascular disease risk in this population.
 

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Citation:

Chanthong P, Lapphra K, Saihongthong S, Sricharoenchai S, Wittawatmongkol O, Phongsamart W, Rungmaitree S, Kongstan N, Chokephaibulkit K. Echocardiography and carotid intima-media thickness among asymptomatic HIV-infected adolescents in Thailand. AIDS. 2014 Sep 10;28(14):2071-9. doi: 10.1097/QAD.0000000000000376. PubMed PMID: 25265075.