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Home >> Publications >> Hepatitis C viremia and the risk of chronic kidney disease in HIV-infected individuals.

Publication

Author(s):

Lucas GM, Jing Y, Sulkowski M, Abraham AG, Estrella MM, Atta MG, Fine DM, Klein MB, Silverberg MJ, Gill MJ, Moore RD, Gebo KA, Sterling TR, Butt AA; NA-ACCORD of the IeDEA.

Pub Title:

Hepatitis C viremia and the risk of chronic kidney disease in HIV-infected individuals.

Pub Date:

Oct 15 2013

Page Number:
1240-9

Journal:

Title: 
Journal of infectious Diseases
Link: 
http://jid.oxfordjournals.org/content/208/8/1240.long

PubMed: 23904290
Pub PDF: PDF icon 23904290.pdf

Abstract
BACKGROUND
: The role of active hepatitis C virus (HCV) replication in chronic kidney disease (CKD) risk has not been clarified.

METHODS: We compared CKD incidence in a large cohort of HIV-infected subjects who were HCV seronegative, HCV viremic (detectable HCV RNA), or HCV aviremic (HCV seropositive, undetectable HCV RNA). Stages 3 and 5 CKD were defined according to standard criteria. Progressive CKD was defined as a sustained 25% glomerular filtration rate (GFR) decrease from baseline to a GFR < 60 mL/min/1.73 m2. We used Cox models to calculate adjusted hazard ratios (HRs) and 95% confidence intervals (CIs).

RESULTS: A total of 52 602 HCV seronegative, 9508 HCV viremic, and 913 HCV aviremic subjects were included. Compared with HCV seronegative subjects, HCV viremic subjects were at increased risk for stage 3 CKD (adjusted HR 1.36 [95% CI, 1.26, 1.46]), stage 5 CKD (1.95 [1.64, 2.31]), and progressive CKD (1.31 [1.19, 1.44]), while HCV aviremic subjects were also at increased risk for stage 3 CKD (1.19 [0.98, 1.45]), stage 5 CKD (1.69 [1.07, 2.65]), and progressive CKD (1.31 [1.02, 1.68]).

CONCLUSIONS: Compared with HIV-infected subjects who were HCV seronegative, both HCV viremic and HCV aviremic individuals were at increased risk for moderate and advanced CKD.

KEYWORDS
: HIV, chronic kidney disease, cohort study, glomerular filtration rate, hepatitis C RNA, hepatitis C virus, injection drug use

PMID: 23904290 [PubMed - in process]

PMCID: PMC3778973 [Available on 2014/10/15]

 

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Citation:

Lucas GM, Jing Y, Sulkowski M, Abraham AG, Estrella MM, Atta MG, Fine DM, Klein MB, Silverberg MJ, Gill MJ, Moore RD, Gebo KA, Sterling TR, Butt AA; NA-ACCORD of the IeDEA. Hepatitis C viremia and the risk of chronic kidney disease in HIV-infected individuals. J Infect Dis. 2013 Oct 15;208(8):1240-9. doi: 10.1093/infdis/jit373. Epub 2013 Jul 31. PubMed PMID: 23904290; PubMed Central PMCID: PMC3778973.