LOGIN

International Epidemiology Databases to Evaluate AIDS

Home >> Publications >> HIV infection, viral hepatitis and liver fibrosis among prison inmates in West Africa.

Publication

Author(s):

Jaquet A1,2, Wandeler G3,4,5, Tine J3, Dagnra CA6, Attia A7, Patassi A8, Ndiaye A9, de Ledinghen V10, Ekouevi DK11,12,13, Seydi M3, Dabis F11,12.

Pub Title:

HIV infection, viral hepatitis and liver fibrosis among prison inmates in West Africa.

Pub Date:

Jun 6 2016

Pub Region(s):

West Africa

Journal:

Title: 
BMC Infect Dis
Link: 
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4895802/

PubMed: 27267370
Pub PDF:

BACKGROUND: Prisoners represent a vulnerable population for blood-borne and sexually transmitted infections which can potentially lead to liver fibrosis and ultimately cirrhosis. However, little is known about the prevalence of liver fibrosis and associated risk factors among inmates in sub-Saharan Africa.

METHODS: Screening of liver fibrosis was undertaken in a randomly selected sample of male inmates incarcerated in Lome, Togo and in Dakar, Senegal using transient elastography. A liver stiffness measurement ≥9.5 KPa was retained to define the presence of a severe liver fibrosis. All included inmates were also screened for HIV, Hepatitis B Virus (HBV) and Hepatitis C Virus (HCV) infection. Substances abuse including alcohol, tobacco and cannabis use were assessed during face-to-face interviews. Odds Ratio (OR) estimates were computed with their 95 % Confidence Interval (CI) to identify factors associated with severe liver fibrosis.

RESULTS: Overall, 680 inmates were included with a median age of 30 years [interquartile range: 24-35]. The prevalence of severe fibrosis was 3.1 % (4.9 % in Lome and 1.2 % in Dakar). Infections with HIV, HBV and HCV were identified in 2.6 %, 12.5 % and 0.5 % of inmates, respectively. Factors associated with a severe liver fibrosis were HIV infection (OR = 7.6; CI 1.8-32.1), HBV infection (OR = 4.8; CI 1.8-12.8), HCV infection (OR = 52.6; CI 4.1-673.8), use of traditional medicines (OR = 3.7; CI 1.4-10.1) and being incarcerated in Lome (OR = 3.3; CI 1.1-9.8) compared to Dakar.

CONCLUSIONS: HIV infection and viral hepatitis infections were identified as important and independent determinants of severe liver fibrosis. While access to active antiviral therapies against HIV and viral hepatitis expands in Africa, adapted strategies for the monitoring of liver disease need to be explored, especially in vulnerable populations such as inmates.

The following websites provide guidelines and policies when citing from PubMed®: http://www.ncbi.nlm.nih.gov/books/NBK7243/
http://www.nlm.nih.gov/bsd/policy/cit_format.html

Citation:

BMC Infect Dis. 2016 Jun 6;16:249. doi: 10.1186/s12879-016-1601-4. HIV infection, viral hepatitis and liver fibrosis among prison inmates in West Africa. Jaquet A1,2, Wandeler G3,4,5, Tine J3, Dagnra CA6, Attia A7, Patassi A8, Ndiaye A9, de Ledinghen V10, Ekouevi DK11,12,13, Seydi M3, Dabis F11,12.