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Home >> Publications >> The impact of fasting on the interpretation of triglyceride levels for predicting myocardial infarction risk in HIV-positive individuals: the D:A:D study.

Publication

Author(s):

D:A:D Study Writing Committee: Kamara DA, Worm SW, Reiss P, Rickenbach, M, Phillips A, Kirk O, D'Arminio Monforte A, Bruyand M, Law MG, deWit S, Smith CJ, Pradier C, Lundgren J, Sabin CA.

Pub Title:

The impact of fasting on the interpretation of triglyceride levels for predicting myocardial infarction risk in HIV-positive individuals: the D:A:D study.

Pub Date:

Aug 15 2011

Pub Region(s):

Asia-Pacific

Journal Issue:

4

Page Number:
521-5

Journal:

Title: 
Journal of Infectious Diseases
Link: 
http://jid.oxfordjournals.org/content/204/4/521.long

PubMed: 21791653
Pub PDF: PDF icon 21791653.pdf

Abstract
We assessed whether fasting modifies the prognostic value of these measurements for the risk of myocardial infarction (MI). Analyses used mixed effect models and Poisson regression. After confounders were controlled for, fasting triglyceride levels were, on average, 0.122 mmol/L lower than nonfasting levels. Each 2-fold increase in the latest triglyceride level was associated with a 38% increase in MI risk (relative rate, 1.38; 95% confidence interval, 1.26-1.51); fasting status did not modify this association. Our results suggest that it may not be necessary to restrict analyses to fasting measurements when considering MI risk.

PMID: 21791653 [PubMed - indexed for MEDLINE]

PMCID: PMC3203386

 

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Citation:

Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) Study. The impact of fasting on the interpretation of triglyceride levels for predicting myocardial infarction risk in HIV-positive individuals: the D:A:D study. J Infect Dis. 2011 Aug 15;204(4):521-5. doi: 10.1093/infdis/jir329. PubMed PMID: 21791653; PubMed Central PMCID: PMC3203386.