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Home >> Publications >> The impact of HIV status, HIV disease progression, and post-traumatic stress symptoms on the health-related quality of life of Rwandan women genocide survivors.

Publication

Author(s):

Gard TL, Hoover DR, Shi Q, Cohen MH, Mutimura E, Adedimeji AA, Anastos K.

Pub Title:

The impact of HIV status, HIV disease progression, and post-traumatic stress symptoms on the health-related quality of life of Rwandan women genocide survivors.

Pub Date:

Oct 31 2012

Pub Region(s):

Central Africa

Journal Issue:

Epub

Page Number:
Epub

Journal:

Title: 
Quality of Life Research
Link: 
http://link.springer.com/article/10.1007%2Fs11136-012-0328-y

PubMed: 23271207
Pub PDF: PDF icon 23271207.pdf

Abstract
PURPOSE
: We examined whether established associations between HIV disease and HIV disease progression on worse health-related quality of life (HQOL) were applicable to women with severe trauma histories, in this case Rwandan women genocide survivors, the majority of whom were HIV-infected. Additionally, this study attempted to clarify whether post-traumatic stress symptoms were uniquely associated with HQOL or confounded with depression.

METHODS: The Rwandan Women's Interassociation Study and Assessment was a longitudinal prospective study of HIV-infected and uninfected women. At study entry, 922 women (705 HIV+ and 217 HIV-) completed measures of symptoms of post-traumatic stress and HQOL as well as other demographic, clinical, and behavioral characteristics.

RESULTS: Even after controlling for potential confounders and mediators, HIV+ women, in particular those with the lowest CD4 counts, scored significantly worse on HQOL and overall quality of life (QOL) than did HIV- women. Even after controlling for depression and HIV disease progression, women with more post-traumatic stress symptoms scored worse on HQOL and overall QOL than women with fewer post-traumatic stress symptoms.

CONCLUSIONS: This study demonstrated that post-traumatic stress symptoms were independently associated with HQOL and overall QOL, independent of depression and other confounders or potential mediators. Future research should examine whether the long-term impact of treatment on physical and psychological symptoms of HIV and post-traumatic stress symptoms would generate improvement in HQOL.

PMID: 23271207 [PubMed - in process]

 

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Citation:

Gard TL, Hoover DR, Shi Q, Cohen MH, Mutimura E, Adedimeji AA, Anastos K. The impact of HIV status, HIV disease progression, and post-traumatic stress symptoms on the health-related quality of life of Rwandan women genocide survivors. Qual Life Res. 2013 Oct;22(8):2073-84. doi: 10.1007/s11136-012-0328-y. Epub 2012 Dec 28. PubMed PMID: 23271207.