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Home >> Publications >> Impact of the immune reconstitution inflammatory syndrome (IRIS) on mortality and morbidity in HIV-infected patients in Mexico.

Publication

Author(s):

Hoyo-Ulloa I, Belaunzarên-Zamudio PF, Crabtree-Ramirez B, Galindo-Fraga A, Pê©rez-Aguinaga ME, Sierra-Madero JG.

Pub Title:

Impact of the immune reconstitution inflammatory syndrome (IRIS) on mortality and morbidity in HIV-infected patients in Mexico.

Pub Date:

Jun 30 2011

Journal Issue:

6

Page Number:
e408-14

Journal:

Title: 
International Journal of Infectious Diseases
Link: 
http://www.ijidonline.com/article/S1201-9712%2811%2900050-6/abstract

PubMed: 21493116
Pub PDF: PDF icon 21493116.pdf

Abstract
OBJECTIVES
: To estimate the impact of immune reconstitution inflammatory syndrome (IRIS) on morbidity and mortality in patients starting highly-active antiretroviral therapy (HAART).

METHODS: A retrospective cohort study of HIV-positive patients starting HAART was conducted at a tertiary care referral center in Mexico City. We estimated the incidence of IRIS, hospitalizations and death rates during the first 2 years of HAART. The relative risk of death (RR) and hospitalization for patients with IRIS were adjusted for relevant covariates using regression methods.

RESULTS: During the 2-year follow-up period, 27% of patients developed IRIS (14 IRIS cases per 100 person-years). The relative risk of death among patients who developed IRIS was 3 times higher (95% confidence interval (CI) 1.19-7.65, p = 0.03). After adjusting for previous opportunistic infections we still observed a higher death rate among patients with IRIS (RR 2.3, 95% CI 0.9-5.9, p=0.09). An effect modification of IRIS over mortality was observed by previous opportunistic infection.

CONCLUSIONS: IRIS-associated mortality is strongly confounded by previous opportunistic infection. Patients with AIDS who eventually developed IRIS had the highest risk of death at the 2-year follow-up.

Copyright © 2011 International Society for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

PMID: 21493116 [PubMed - indexed for MEDLINE]

PMCID: PMC3732828

 

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Citation:

Hoyo-Ulloa I, Belaunzarán-Zamudio PF, Crabtree-Ramirez B, Galindo-Fraga A, Pérez-Aguinaga ME, Sierra-Madero JG. Impact of the immune reconstitution inflammatory syndrome (IRIS) on mortality and morbidity in HIV-infected patients in Mexico. Int J Infect Dis. 2011 Jun;15(6):e408-14. doi: 10.1016/j.ijid.2011.02.007. Epub 2011 Apr 13. PubMed PMID: 21493116; PubMed Central PMCID: PMC3732828.