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Home >> Publications >> Invasive cervical cancer risk among HIV-infected women: A North American multi-cohort collaboration prospective study.

Publication

Author(s):

Abraham AG, Strickler HD, Jing Y, Gange SJ, Sterling TR, Silverberg M, Saag M, Rourke S, Rachlis A, Napravnik S, Moore RD, Klein M, Kitahata M, Kirk G, Hogg R, Hessol NA, Goedert JJ, Gill MJ, Gebo K, Eron JJ, Engels EA, Dubrow R, Crane HM, Brooks JT, Bosch R, D'Souza G.

Pub Title:

Invasive cervical cancer risk among HIV-infected women: A North American multi-cohort collaboration prospective study.

Pub Date:

Aug 15 2013

Journal:

Title: 
JAIDS- Journal of Acquired Immune Deficiency Syndromes (JAIDS)
Link: 
http://journals.lww.com/jaids/pages/articleviewer.aspx?year=2013&issue=04010&article=00006&type=abstract

PubMed: 23254153
Pub PDF: PDF icon 23254153.pdf

Abstract
OBJECTIVE
: HIV infection and low CD4+ T-cell count are associated with an increased risk of persistent oncogenic human papillomavirus infection-the major risk factor for cervical cancer. Few reported prospective cohort studies have characterized the incidence of invasive cervical cancer (ICC) in HIV-infected women.

METHODS: Data were obtained from HIV-infected and -uninfected female participants in the North American AIDS Cohort Collaboration on Research and Design with no history of ICC at enrollment. Participants were followed from study entry or January 1996 through ICC, loss to follow-up, or December 2010. The relationship of HIV infection and CD4+ T-cell count with risk of ICC was assessed using age-adjusted Poisson regression models and standardized incidence ratios. All cases were confirmed by cancer registry records and/or pathology reports. Cervical cytology screening history was assessed through medical record abstraction.

RESULTS: A total of 13,690 HIV-infected and 12,021 HIV-uninfected women contributed 66,249 and 70,815 person-years of observation, respectively. Incident ICC was diagnosed in 17 HIV-infected and 4 HIV-uninfected women (incidence rate of 26 and 6 per 100,000 person-years, respectively). HIV-infected women with baseline CD4+ T-cells of ≥350, 200-349, and <200 cells per microliter had a 2.3, 3.0, and 7.7 times increase in ICC incidence, respectively, compared with HIV-uninfected women (P(trend) = 0.001). Of the 17 HIV-infected women, medical records for the 5 years before diagnosis showed that 6 had no documented screening, 5 had screening with low-grade or normal results, and 6 had high-grade results.

CONCLUSIONS: This study found elevated incidence of ICC in HIV-infected compared with -uninfected women, and these rates increased with immunosuppression.

Comment in

PMID: 23254153 [PubMed - indexed for MEDLINE]

PMCID: PMC3633634 [Available on 2014/4/1]

 

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Citation:

Abraham AG, D'Souza G, Jing Y, Gange SJ, Sterling TR, Silverberg MJ, Saag MS, Rourke SB, Rachlis A, Napravnik S, Moore RD, Klein MB, Kitahata MM, Kirk GD, Hogg RS, Hessol NA, Goedert JJ, Gill MJ, Gebo KA, Eron JJ, Engels EA, Dubrow R, Crane HM, Brooks JT, Bosch RJ, Strickler HD; North American AIDS Cohort Collaboration on Research and Design of IeDEA. Invasive cervical cancer risk among HIV-infected women: a North American multicohort collaboration prospective study. J Acquir Immune Defic Syndr. 2013 Apr 1;62(4):405-13. doi: 10.1097/QAI.0b013e31828177d7. PubMed PMID: 23254153; PubMed Central PMCID: PMC3633634.