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Home >> Publications >> Late Presentation into Care of HIV Disease and Its Associated Factors in Asia: Results of TAHOD.

Publication

Author(s):

Jeong SJ1, Italiano C2, Chaiwarith R3, Ng OT4, Vanar S2, Jiamsakul A5, Saphonn V6, Nguyen KV7, Kiertiburanakul S8, Lee MP9, Merati TP10, Pham TT11, Yunihastuti E12, Ditangco R13, Kumarasamy N14, Zhang F15, Wong W16, Sim BL17, Pujari S18, Kantipong P19, Phanuphak P20, Ratanasuwan W21, Oka S22, Mustafa M23, Durier N24, Choi JY1.

Pub Title:

Late Presentation into Care of HIV Disease and Its Associated Factors in Asia: Results of TAHOD.

Pub Date:

Mar 1 2016

Pub Region(s):

Asia-Pacific

Journal:

Title: 
AIDS Res Hum Retroviruses

PubMed: 26414065
Pub PDF:

Many HIV-infected individuals do not enter health care until late in the infection course. Despite encouraging earlier testing, this situation has continued for several years. We investigated the prevalence of late presenters and factors associated with late presentation among HIV-infected patients in an Asian regional cohort. This cohort study included HIV-infected patients with their first positive HIV test during 2003-2012 and CD4 count and clinical status data within 3 months of that test. Factors associated with late presentation into care (CD4 count <200 cells/μl or an AIDS-defining event within ±3 months of first positive HIV test) were analyzed in a random effects logistic regression model. Among 3,744 patients, 2,681 (72%) were late presenters. In the multivariable model, older patients were more likely to be late presenters than younger (≤30 years) patients [31-40, 41-50, and ≥51 years: odds ratio (OR) = 1.57, 95% confidence interval (CI) 1.31-1.88; OR = 2.01, 95% CI 1.58-2.56; and OR = 1.69, 95% CI 1.23-2.31, respectively; all p ≤ 0.001]. Injecting drug users (IDU) were more likely (OR = 2.15, 95% CI 1.42-3.27, p < 0.001) and those with homosexual HIV exposure were less likely (OR = 0.45, 95% CI 0.35-0.58, p < 0.001) to be late presenters compared to those with heterosexual HIV exposure. Females were less likely to be late presenters (OR = 0.44, 95% CI 0.36-0.53, p < 0.001). The year of first positive HIV test was not associated with late presentation. Efforts to reduce the patients who first seek HIV care at the late stage are needed. The identified risk factors associated with late presentation should be utilized in formulating targeted public health intervention to improve earlier entry into HIV care.

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Citation:

AIDS Res Hum Retroviruses. 2016 Mar;32(3):255-61. doi: 10.1089/AID.2015.0058. Epub 2015 Oct 15. Late Presentation into Care of HIV Disease and Its Associated Factors in Asia: Results of TAHOD. Jeong SJ1, Italiano C2, Chaiwarith R3, Ng OT4, Vanar S2, Jiamsakul A5, Saphonn V6, Nguyen KV7, Kiertiburanakul S8, Lee MP9, Merati TP10, Pham TT11, Yunihastuti E12, Ditangco R13, Kumarasamy N14, Zhang F15, Wong W16, Sim BL17, Pujari S18, Kantipong P19, Phanuphak P20, Ratanasuwan W21, Oka S22, Mustafa M23, Durier N24, Choi JY1.