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Home >> Publications >> No excess risk of follicular lymphoma in kidney transplant and HIV-related immunodeficiency.

Publication

Author(s):

Vajdic CM, van Leeuwen MT, Turner JJ, McDonald AM, Webster AC, McDonald SP, Chapman JR, Kaldor JM, Grulich AE.

Pub Title:

No excess risk of follicular lymphoma in kidney transplant and HIV-related immunodeficiency.

Pub Date:

Dec 1 2010

Pub Region(s):

Asia-Pacific

Journal Issue:

11

Page Number:
2732-5

Journal:

Title: 
International Journal of Cancer
Link: 
http://onlinelibrary.wiley.com/doi/10.1002/ijc.25272/abstract

PubMed: 20178100
Pub PDF: PDF icon 20178100.pdf

Abstract
Subtype-specific incidence patterns in populations at high risk of lymphoma offer insight into lymphomagenesis. The incidence profiles for the 2 most common non-Hodgkin lymphoma subtypes were compared for 2 immunodeficient populations, adults receiving a kidney transplant 1982-2003 (n = 7,730) or diagnosed with human immunodeficiency virus (HIV) infection 1982-2004 (n = 17,175). National, population-based registries were linked and standardized incidence ratios (SIRs) were computed for each cohort and lymphoma subtype. Risk of diffuse large B-cell lymphoma was significantly increased after transplantation (SIR 17.83, 95% CI: 13.61-22.95) and after HIV infection (SIR 58.81, 95% CI: 52.59-65.56). Rates of follicular lymphoma (FL) were neither significantly increased nor decreased in transplant recipients (SIR 0.82, 95% CI: 0.10-2.96) and in people with HIV (SIR 1.25, 95% CI: 0.41-2.91). The findings argue against an infectious or other immunodeficiency-related etiology for FL and clearly differentiate it from diffuse large B-cell lymphoma.

PMID: 20178100 [PubMed - indexed for MEDLINE]

 

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Citation:

Vajdic CM, van Leeuwen MT, Turner JJ, McDonald AM, Webster AC, McDonald SP, Chapman JR, Kaldor JM, Grulich AE. No excess risk of follicular lymphoma in kidney transplant and HIV-related immunodeficiency. Int J Cancer. 2010 Dec 1;127(11):2732-5. doi: 10.1002/ijc.25272. PubMed PMID: 20178100.