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Meless D, Ba B, Faye M, Diby JS, N'zoré S, Datté S, Diecket L, N'diaye C, Aka EA, Kouakou K, Ba A, Ekouévi DK, Dabis F, Shiboski C, Arrivé E.An MW, Frangakis CE, Yiannoutsos CT.

Pub Title:

Oral lesions among HIV-infected children on antiretroviral treatment in West Africa.

Pub Date:

Mar 31 2014

Pub Region(s):

West Africa


Tropical Medicine and International Health

PubMed: 24386972
Pub PDF:

To estimate the prevalence of oral mucosal diseases and dental caries among HIV-infected children receiving antiretroviral treatment (ART) in West Africa and to identify the factors associated with the prevalence of oral mucosal lesions.

METHODS: Multicentre cross-sectional survey in five paediatric HIV clinics in Côte d'Ivoire, Mali and Sénégal. A standardised examination was performed by trained dentists on a random sample of HIV-infected children aged 5-15 years receiving ART. The prevalence of oral and dental lesions and mean number of decayed, missing/extracted and filled teeth (DMFdefT) in temporary and permanent dentition were estimated with their 95% confidence interval (95% CI). We used logistic regression to explore the association between children's characteristics and the prevalence of oral mucosal lesions, expressed as prevalence odds ratio (POR).

RESULTS: The median age of the 420 children (47% females) enrolled was 10.4 years [interquartile range (IQR) = 8.3-12.6]. The median duration on ART was 4.6 years (IQR = 2.6-6.2); 84 (20.0%) had CD4 count<350 cells/mm3 . A total of 35 children (8.3%; 95% CI: 6.1-11.1) exhibited 42 oral mucosal lesions (24 were candidiasis); 86.0% (95% CI = 82.6-89.3) of children had DMFdefT ≥ 1. The presence of oral mucosal lesions was independently associated with CD4 count < 350 cells/mm3 (POR = 2.96, 95% CI = 1.06-4.36) and poor oral hygiene (POR = 2.69, 95% CI = 1.07-6.76).

CONCLUSIONS: Oral mucosal lesions still occur in HIV-infected African children despite ART, but rarely. However, dental caries were common and severe in this population, reflecting the need to include oral health in the comprehensive care of HIV.

© 2014 John Wiley & Sons Ltd.


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An MW, Frangakis CE, Yiannoutsos CT. Choosing profile double-sampling designs for survival estimation with application to President's Emergency Plan for AIDS Relief evaluation. Stat Med. 2014 Jan 10. doi: 10.1002/sim.6087. [Epub ahead of print] PubMed PMID: 24408038.