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Home >> Publications >> Plasma HIV-2 RNA According to CD4 Count Strata among HIV-2-Infected Adults in the IeDEA West Africa Collaboration.

Publication

Author(s):

Ekouévi DK, Avettand-Fènoël V, Tchounga BK, Coffie PA, Sawadogo A, Minta D, Minga A, Eholie SP, Plantier JC, Damond F, Dabis F, Rouzioux C; IeDEA West Africa collaboration.

Pub Title:

Plasma HIV-2 RNA According to CD4 Count Strata among HIV-2-Infected Adults in the IeDEA West Africa Collaboration.

Pub Date:

Jun 25 2015

Pub Region(s):

West Africa

Journal:

Title: 
PLoS One
Link: 
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0129886

PubMed: 26111242

Abstract

BACKGROUND:

Plasma HIV-1 RNA monitoring is one of the standard tests for the management of HIV-1 infection. While HIV-1 RNA can be quantified using several commercial tests, no test has been commercialized for HIV-2 RNA quantification. We studied the relationship betweenplasma HIV-2 viral load (VL) and CD4 count in West African patients who were either receiving antiretroviral therapy (ART) or treatment-naïve.

METHOD:

A cross sectional survey was conducted among HIV-2-infected individuals followed in three countries in West Africa from March to December 2012. All HIV-2 infected-patients who attended one of the participating clinics were proposed a plasma HIV-2 viral load measurement.HIV-2 RNA was quantified using the new ultrasensitive in-house real-time PCR assay with a detection threshold of 10 copies/ mL (cps/mL).

RESULTS:

A total of 351 HIV-2-infected individuals participated in this study, of whom 131 (37.3%) were treatment naïve and 220 (62.7%) had initiated ART. Among treatment-naïve patients, 60 (46.5%) had undetectable plasma HIV-2 viral load (<10 cps/mL), it was detectable between 10-100 cps/mL in 35.8%, between 100-1000 cps/mL in 11.7% and >1000 cps/mL in 6.0% of the patients. Most of the treatment-naïve patients (70.2%) had CD4-T cell count ≥500 cells/mm3 and 43 (46.7%) of these patients had a detectable VL (≥10 cps/mL). Among the 220 patients receiving ART, the median CD4-T cell count rose from 231 to 393 cells/mm3 (IQR [259-561]) after a median follow-up duration of 38 months and 145 (66.0%) patients had CD4-T cell count ≤ 500 cells/mm3 with a median viral load of 10 cps/mL (IQR [10-33]). Seventy five (34.0%) patients had CD4-T cellcount ≥ 500 cells/mm3, among them 14 (18.7%) had a VL between 10-100 cps/mL and 2 (2.6%) had VL >100 cps/mL.

CONCLUSION:

This study suggests that the combination of CD4-T cell count and ultrasensitive HIV-2 viral load quantification with a threshold of 10 cps/mL, could improve ART initiation among treatment naïve HIV-2-infected patients and the monitoring of ART response among patients receiving treatment.

 

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Citation:

Ekouévi DK, Avettand-Fènoël V, Tchounga BK, Coffie PA, Sawadogo A, Minta D, Minga A, Eholie SP, Plantier JC, Damond F, Dabis F, Rouzioux C; IeDEA West Africa collaboration. Plasma HIV-2 RNA According to CD4 Count Strata among HIV-2-Infected Adults in the IeDEA West Africa Collaboration. PLoS One. 2015 Jun 25;10(6):e0129886. doi: 10.1371/journal.pone.0129886. eCollection 2015. PubMed PMID: 26111242; PubMed Central PMCID: PMC4482391.