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Home >> Publications >> Predictors of Clinical Progression in HIV-1-Infected Adults Initiating Combination Antiretroviral Therapy with Advanced Disease in the Asia Pacific Region: Results from the TREAT Asia HIV Observational Database.

Publication

Author(s):

Byakwaga H, Petoumenos K, Ananworanich J, Zhang F, Boyd MA, Sirisanthana T, Li PC, Lee C, Mean CV, Saphonn V, Omar SF, Pujari S, Phanuphak P, Lim PL, Kumarasamy N, Chen YM, Merati TP, Sungkanuparph S, Ditangco R, Oka S, Tau G, Zhou J, Law MG, Emery S.

Pub Title:

Predictors of Clinical Progression in HIV-1-Infected Adults Initiating Combination Antiretroviral Therapy with Advanced Disease in the Asia Pacific Region: Results from the TREAT Asia HIV Observational Database.

Pub Date:

Jul 19 2013

Pub Region(s):

Asia-Pacific

Journal Issue:

Epub

Page Number:
Epub

Journal:

Title: 
Journal of the International Association of Physicians AIDS Care (Chicago)
Link: 
http://jia.sagepub.com/content/early/2013/02/19/1545109712469684.long

PubMed: 23422741
Pub PDF: PDF icon nihms464478.pdf

Abstract
The majority of HIV-infected patients in developing countries commences combination antiretroviral therapy (cART) with advanced disease. We examined predictors of disease progression in patients initiating cART with CD4 count ≤200 cells/mm(3) in the TREAT Asia HIV Observational Database. The main outcome measure was progression to either an AIDS-defining illness or death occurring 6 months after initiation of cART. We used survival analysis methods. A total of 1255 patients contributed 2696 person years of follow-up; 73 were diagnosed with AIDS and 9 died. The rate of progression to the combined end point was 3.0 per 100 person years. The factors significantly associated with a higher risk of disease progression were Indian ethnicity, infection through intravenous drug use, lower CD4 count, and hemoglobin ≤130 g/dL at 6 months. In conclusion, measurements of CD4 count and hemoglobin at month 6 may be useful for early identification of disease progression in resource-limited settings.

KEYWORDS:

HIV, antiretroviral therapy, disease progression, resource-limited settings

PMID: 23422741 [PubMed - indexed for MEDLINE]

PMCID: PMC3716846

 

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Citation:

Byakwaga H, Petoumenos K, Ananworanich J, Zhang F, Boyd MA, Sirisanthana T, Li PC, Lee C, Mean CV, Saphonn V, Omar SF, Pujari S, Phanuphak P, Lim PL, Kumarasamy N, Chen YM, Merati TP, Sungkanuparph S, Ditangco R, Oka S, Tau G, Zhou J, Law MG, Emery S. Predictors of clinical progression in HIV-1-infected adults initiating combination antiretroviral therapy with advanced disease in the Asia-Pacific region: results from the TREAT Asia HIV observational database. J Int Assoc Provid AIDS Care. 2013 Jul-Aug;12(4):270-7. doi: 10.1177/1545109712469684. Epub 2013 Feb 19. PubMed PMID: 23422741; PubMed Central PMCID: PMC3716846.