LOGIN

International Epidemiology Databases to Evaluate AIDS

Home >> Publications >> Prevalence, characteristics, management, and outcome of pulmonary tuberculosis in HIV-infected children in the TREAT Asia pediatric HIV Observational Database (TApHOD).

Publication

Author(s):

Sudjaritruk T, Maleesatharn A, Prasitsuebsai W, Fong SM, Le NO, Le TT, Lumbiganon P, Kumarasamy N, Kurniati N, Hansudewechakul R, Yusoff NK, Razali KA, Kariminia A, Sohn AH, Sirisanthana V; TREAT Asia Pediatric HIV Observational Database.

Pub Title:

Prevalence, characteristics, management, and outcome of pulmonary tuberculosis in HIV-infected children in the TREAT Asia pediatric HIV Observational Database (TApHOD).

Pub Date:

Dec 31 2013

Pub Region(s):

Asia-Pacific

Journal:

Title: 
AIDS Patient Care and STDs
Link: 
http://online.liebertpub.com/doi/abs/10.1089/apc.2013.0236

PubMed: 24206012
Pub PDF:

Abstract
A multicenter, retrospective, observational study was conducted to determine prevalence, characteristics, management, and outcome of pulmonary tuberculosis (PTB) in Asian HIV-infected children in the TREAT Asia Pediatric HIV Observational Database (TApHOD). Data on PTB episodes diagnosed during the period between 12 months before antiretroviral therapy (ART) initiation and December 31, 2009 were extracted. A total of 2678 HIV-infected children were included in TApHOD over a 13-year period; 457 developed PTB, giving a period prevalence of 17.1% (range 5.7-33.0% per country). There were a total of 484 PTB episodes; 27 children had 2 episodes each. There were 21 deaths (4.3%). One third of episodes (n=175/484) occurred after ART initiation at a median of 14.1 months (interquartile range [IQR] 2.5-28.8 months). The median (IQR) CD4+ values were 9.0% (3.0-16.0%) and 183.5 (37.8-525.0) cells/mm(3) when PTB was diagnosed. Most episodes (n=424/436, 97.3%) had abnormal radiographic findings compatible with PTB, whereas half (n=267/484, 55.2%) presented with clinical characteristics of PTB. One third of those tested (n=42/122, 34.4%) had bacteriological evidence of PTB. Of the 156 episodes (32.2%) that were accompanied with extrapulmonary TB, pleuritis was the most common manifestation (81.4%). After treatment completion, most episodes (n=396/484, 81.9%) were recorded as having positive outcomes (cured, treatment completed and child well, and improvement). The prevalence of PTB among Asian HIV-infected children in our cohort was high. Children with persistent immunosuppression remain vulnerable to PTB even after ART initiation.

The following websites provide guidelines and policies when citing from PubMed®: http://www.ncbi.nlm.nih.gov/books/NBK7243/
http://www.nlm.nih.gov/bsd/policy/cit_format.html

Citation:

Sudjaritruk T, Maleesatharn A, Prasitsuebsai W, Fong SM, Le NO, Le TT, Lumbiganon P, Kumarasamy N, Kurniati N, Hansudewechakul R, Yusoff NK, Razali KA, Kariminia A, Sohn AH, Sirisanthana V; TREAT Asia Pediatric HIV Observational Database. Prevalence, characteristics, management, and outcome of pulmonary tuberculosis in HIV-infected children in the TREAT Asia pediatric HIV Observational Database (TApHOD). AIDS Patient Care STDS. 2013 Dec;27(12):649-56. doi: 10.1089/apc.2013.0236. Epub 2013 Nov 9. PubMed PMID: 24206012; PubMed Central PMCID: PMC3868296.