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Home >> Publications >> Regional differences in predictive accuracy of WHO immunologic failure criteria.

Publication

Author(s):

Kiragga AN, Castelnuovo B, Kamya MR, Moore R, Manabe YC.

Pub Title:

Regional differences in predictive accuracy of WHO immunologic failure criteria.

Pub Date:

Mar 27 2012

Journal Issue:

26(6)

Page Number:
768-70

Journal:

Title: 
AIDS
Link: 
http://bit.ly/1bmJDjH

PubMed: 22269974
Pub PDF: PDF icon 22269974.pdf

Abstract
We compared the performance of the WHO immunologic criteria for treatment failure among Uganda and American patients. Antiretroviral treatment-naive patients with a CD4 T-cell count less than 200 cells/μl or AIDS at enrollment on a nonnucleoside reverse transcriptase inhibitors-based regimen for more than 1 year were selected. For all criteria, the positive predictive value was significantly higher in the American compared with the Ugandan patients. Population-specific guidelines should be developed using large African cohorts to identify more specific and sensitive criteria.

PMID: 22269974 [PubMed - indexed for MEDLINE]

PMCID: PMC3812797

 

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Citation:

Kiragga AN, Castelnuovo B, Kamya MR, Moore R, Manabe YC. Regional differences in predictive accuracy of WHO immunologic failure criteria. AIDS. 2012 Mar 27;26(6):768-70. doi: 10.1097/QAD.0b013e32835143e3. PubMed PMID: 22269974; PubMed Central PMCID: PMC3812797.