LOGIN

International Epidemiology Databases to Evaluate AIDS

Home >> Publications >> Survival of HIV-infected children: a cohort study from the Asia Pacific region.

Publication

Author(s):

Lumbiganon P, Kariminia A, Aurpibul L, Hansudewechakul R, Puthanakit T, Kurniati N, Kumarasamy N, Chokephaibulkit K, Nik Yusoff NK, Vonthanak S, Moy FS, Razali KA, Nallusamy R, Sohn AH; TREAT Asia Pediatric HIV Observational Database (TApHOD).

Pub Title:

Survival of HIV-infected children: a cohort study from the Asia Pacific region.

Pub Date:

Apr 30 2011

Pub Region(s):

Asia-Pacific

Journal Issue:

4

Page Number:
365-71

Journal:

Title: 
JAIDS- Journal of Acquired Immune Deficiency Syndromes
Link: 
http://journals.lww.com/jaids/pages/articleviewer.aspx?year=2011&issue=04010&article=00012&type=abstract

PubMed: 21160429
Pub PDF: PDF icon 21160429.pdf

Abstract
BACKGROUND
: Combination antiretroviral therapy (ART) has been used for HIV-infected children in many Asian countries since 2002. This study describes survival outcomes among HIV-infected children in a multicenter regional cohort in Asia.

PATIENTS AND METHODS: Retrospective and prospective data collected through March 2009 from children in 5 countries enrolled in TREAT Asia's Pediatric HIV Observational Database were analysed. Multivariate Cox proportional hazard models were used to assess factors associated with mortality in children who received ART.

RESULTS: Among 2280 children, 1752 (77%) had received ART. During a median follow-up of 3.1 years after ART, 115 (6.6%) deaths occurred, giving a crude mortality rate of 1.9 per 100 child-years [95% confidence interval (CI): 1.6 to 2.4]. The mortality rate was highest in the first 3 months of ART (10.2 per 100 child-years; 95% CI: 7.5 to 13.7) and declined after 12 months (0.9 per 100 child-years; 95% CI: 0.7 to 1.3). Those with a low recent CD4 percentage, who started ART with lower baseline weight-for-age Z score, or with WHO clinical stage 4 had an increased risk of death. Of 528 (23%) children who never received ART, 36 (6.8%) died after presenting to care, giving a crude mortality rate of 4.1 per 100 child-years (95% CI: 3.0 to 5.7), with a lost-to-program rate of 31.5 per 100 child-years (95% CI: 28.0 to 35.5).

CONCLUSIONS: The high mortality during the first 3 months of ART and in those with low CD4 percentage support the implementation of early diagnosis and ART initiation.

PMID: 21160429 [PubMed - indexed for MEDLINE]

PMCID: PMC3072816

 

The following websites provide guidelines and policies when citing from PubMed®: http://www.ncbi.nlm.nih.gov/books/NBK7243/
http://www.nlm.nih.gov/bsd/policy/cit_format.html

Citation:

Lumbiganon P, Kariminia A, Aurpibul L, Hansudewechakul R, Puthanakit T, Kurniati N, Kumarasamy N, Chokephaibulkit K, Nik Yusoff NK, Vonthanak S, Moy FS, Razali KA, Nallusamy R, Sohn AH; TREAT Asia Pediatric HIV Observational Database (TApHOD). Survival of HIV-infected children: a cohort study from the Asia-Pacific region. J Acquir Immune Defic Syndr. 2011 Apr;56(4):365-71. doi: 10.1097/QAI.0b013e318207a55b. PubMed PMID: 21160429; PubMed Central PMCID: PMC3072816.