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Home >> Publications >> Transmitted Drug Resistance and Antiretroviral Treatment Outcomes in Non-Subtype B HIV-1-Infected Patients in South East Asia.

Publication

Author(s):

Phanuphak P, Sirivichayakul S, Jiamsakul A, Sungkanuparph S, Kumarasamy N, Lee MP, Sirisanthana T, Kantipong P, Lee C, Kamarulzaman A, Mustafa M, Ditangco R, Merati T, Ratanasuwan W, Singtoroj T, Kantor R.

Pub Title:

Transmitted Drug Resistance and Antiretroviral Treatment Outcomes in Non-Subtype B HIV-1-Infected Patients in South East Asia.

Pub Date:

May 1 2014

Pub Region(s):

Asia-Pacific

Journal:

Title: 
JAIDS- Journal of Acquired Immune Deficiency Syndromes
Link: 
http://ovidsp.tx.ovid.com/sp-3.12.0b/ovidweb.cgi?QS2=434f4e1a73d37e8c504983e01e46c99a8b689d34878d5694d50077f81d1b5dbb708e451607ec3269abba30c21db1a35a9ae2436e5c811f75e953f18456b34c219663075452c60c13c90333c0988a153217be4ea91363a8a8a97a5f3b483dec4e489be59988

PubMed: 24413039
Pub PDF: PDF icon 24413039.pdf

Abstract
BACKGROUND:
We compared treatment outcomes of transmitted drug resistance (TDR) in patients on fully or partially sensitive drug regimens.

METHODS: Factors associated with survival and failure were analyzed using Cox proportional hazards and discrete time conditional logistic models.

RESULTS: TDR, found in 60 (4.1%) of 1471 Asian treatment-naive patients, was one of the significant predictors of failure. Patients with TDR to >1 drug in their regimen were >3 times as likely to fail compared to no TDR.

CONCLUSIONS: TDR was associated with failure in the context of non-fully sensitive regimens. Efforts are needed to incorporate resistance testing into national treatment programs.

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Citation:

Phanuphak P, Sirivichayakul S, Jiamsakul A, Sungkanuparph S, Kumarasamy N, Lee MP, Sirisanthana T, Kantipong P, Lee C, Kamarulzaman A, Mustafa M, Ditangco R, Merati T, Ratanasuwan W, Singtoroj T, Kantor R. Transmitted Drug Resistance and Antiretroviral Treatment Outcomes in Non-Subtype B HIV-1-Infected Patients in South East Asia. J Acquir Immune Defic Syndr. 2014 May 1;66(1):74-9. doi: 10.1097/QAI.0000000000000108. PubMed PMID: 24413039.