LOGIN

International Epidemiology Databases to Evaluate AIDS

Home >> Publications >> In Utero Exposure to Antiretroviral Drugs: Effect on Birth Weight and Growth Among HIV-exposed Uninfected Children in Brazil.

Publication

Author(s):

Hofer CB1, Keiser O, Zwahlen M, Lustosa CS, Frota AC, de Oliveira RH, Abreu TF, Carvalho AW, Araujo LE, Egger M.

Pub Title:

In Utero Exposure to Antiretroviral Drugs: Effect on Birth Weight and Growth Among HIV-exposed Uninfected Children in Brazil.

Pub Date:

Jan 1 2016

Pub Region(s):

Multiregional, Southern Africa

Page Number:
71-77

Journal:

Title: 
Pediatr Infect Dis J
Link: 
http://ovidsp.tx.ovid.com/sp-3.18.0b/ovidweb.cgi?QS2=434f4e1a73d37e8cd5d17abe40274ae4655ad96ae9631e9d2722e91602cd787d1fcc2c1210efe6edffabb441340e12b15be1227e6a066373fc67b00dc14c7cccf4a771bad46e11768addeef790d2ebbbc378648b575fa985a1806a3e927cf1f20818f4ba3a

PubMed: 26741583
BACKGROUND:
There are concerns about the effects of in utero exposure to antiretroviral drugs (ARVs) on the development of HIV-exposed but uninfected (HEU) children. The aim of this study was to evaluate whether in utero exposure to ARVs is associated with lower birth weight/height and reduced growth during the first 2 years of life.
METHODS:
This cohort study was conducted among HEU infants born between 1996 and 2010 in Tertiary children's hospital in Rio de Janeiro, Brazil. Weight was measured by mechanical scale, and height was measured by measuring board. Z-scores for weight-for-age (WAZ), length-for-age (LAZ) and weight-for-length were calculated. We modeled trajectories by mixed-effects models and adjusted for mother's age, CD4 cell count, viral load, year of birth and family income.
RESULTS:
A total of 588 HEU infants were included of whom 155 (26%) were not exposed to ARVs, 114 (19%) were exposed early (first trimester) and 319 (54%) later. WAZ were lower among infants exposed early compared with infants exposed later: adjusted differences were -0.52 (95% confidence interval [CI]: -0.99 to -0.04, P = 0.02) at birth and -0.22 (95% CI: -0.47 to 0.04, P = 0.10) during follow-up. LAZ were lower during follow-up: -0.35 (95% CI: -0.63 to -0.08, P = 0.01). There were no differences in weight-for-length scores. Z-scores of infants exposed late during pregnancy were similar to unexposed infants.
CONCLUSIONS:
In HEU children, early exposure to ARVs was associated with lower WAZ at birth and lower LAZ up to 2 years of life. Growth of HEU children needs to be monitored closely.
The following websites provide guidelines and policies when citing from PubMed®: http://www.ncbi.nlm.nih.gov/books/NBK7243/
http://www.nlm.nih.gov/bsd/policy/cit_format.html

Citation:

Hofer CB, Keiser O, Zwahlen M, Lustosa CS, Frota AC, de Oliveira RH, Abreu TF, Carvalho AW, Araujo LE, Egger M. In Utero Exposure to Antiretroviral Drugs: Effect on Birth Weight and Growth Among HIV-exposed Uninfected Children in Brazil. Pediatr Infect Dis J. 2016 Jan;35(1):71-7. doi: 10.1097/INF.0000000000000926. PubMed PMID: 26741583; PubMed Central PMCID: PMC4705846.