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Home >> Publications >> Weight as predictors of clinical progression and treatment failure: Results from the TREAT Asia Pediatric HIV Observational Database (TApHOD).

Publication

Author(s):

Kariminia A, Durier N, Jourdain G, Saghayam S, Do CV, Nguyen VL, Hansudewechakul R, Lumbiganon P, Chokephaibulkit K, Truong HK, Sirisanthana V, Ung V, Vonthanak S, Ananworanich J, Yusoff NK, Kurniati N, Razali K, Fong SM, Nallusamy R, Wati DK.

Pub Title:

Weight as predictors of clinical progression and treatment failure: Results from the TREAT Asia Pediatric HIV Observational Database (TApHOD).

Pub Date:

Sep 1 2014

Pub Region(s):

Asia-Pacific

Journal:

Title: 
JAIDS- Journal of Acquired Immune Deficiency Syndromes
Link: 
http://ovidsp.tx.ovid.com/sp-3.12.0b/ovidweb.cgi?WebLinkFrameset=1&S=NMOIFPKNLKDDIGBONCMKIFDCINKFAA00&returnUrl=ovidweb.cgi%3fMain%2bSearch%2bPage%3d1%26S%3dNMOIFPKNLKDDIGBONCMKIFDCINKFAA00&directlink=http%3a%2f%2fgraphics.tx.ovid.com%2fovftpdfs%2fFPDDNCD

PubMed: 24872132
Pub PDF: PDF icon 24872132.pdf

Abstract
OBJECTIVE:

To evaluate the value of time-updated weight and height in predicting clinical progression, immunological and virological failure in children receiving combination antiretroviral therapy (cART).

METHODS:
We used Cox regression to analyse data of a cohort of Asian children.

RESULTS:
2608 children were included; median age at cART was 5.7 years. Time-updated weight for age Z score <-3 was associated with mortality (P < 0.001) independent of CD4%; and <-2 was associated with immunological failure (P ≤ 0.03) independent of age at cART.

CONCLUSION:
Weight monitoring provides useful data to inform clinical management of children on cART in resource-limited settings.

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Citation:

Kariminia A, Durier N, Jourdain G, Saghayam S, Do CV, Nguyen VL, Hansudewechakul R, Lumbiganon P, Chokephaibulkit K, Truong HK, Sirisanthana V, Ung V, Vonthanak S, Ananworanich J, Yusoff NK, Kurniati N, Razali K, Fong SM, Nallusamy R, Wati DK. Weight as predictors of clinical progression and treatment failure: Results from the TREAT Asia Pediatric HIV Observational Database (TApHOD). J Acquir Immune Defic Syndr. 2014 May 27. [Epub ahead of print] PubMed PMID: 24872132.