The IeDEA network is an international research consortium established in 2005 by the National Institute of Allergy and Infectious Diseases to provide a rich resource for globally diverse HIV/AIDS data.
Sites in various regions throughout the world collaborate to collect and define key variables, harmonize data, and implement methodology to effectively pool data as a cost-effective means of generating large data sets to address the high priority research questions and streamline HIV/AIDS research. The NICHD Pediatric, Adolescent, and Maternal AIDS (PAMA) Branch has co-funded the IeDEA since 2006, providing support to allow the inclusion of patient data on infants, children, adolescents, and pregnant women. The National Cancer Institute (NCI), Office of HIV and AIDS Malignancy (OHAM) has provided funding for IeDEA since 2007. This funding supports the collection/analyses of data on cancer, one of the leading co-morbidities of HIV/AIDS.
Since 2016, the National Institute of Mental Health (NIMH) and the National Institute on Drug Abuse (NIDA) provide additional funding. NIMH seeks to support projects in mental health that will incorporate methods to increase understanding of the impact of HIV on incidence, prevalence, and spectrum of mental health and neurobehavioral disabilities in the four African regions covered by IeDEA. It is recognized that data on mental health is lacking, and that IeDEA will need to develop methods to collect relevant data. NIDA seeks to support research to increase understanding of the influence of substance use on HIV incidence, prevalence, and treatment outcomes in order to better incorporate substance use into clinical care settings and programs. NIDA has particular interest in focus on African regions (East Africa and Southern Africa), as under-resourced regions which are experiencing rapid increases in injection and non-injection illicit drug use. NIDA also has interest in regions of Asia where stimulant use continues to be a significant driver of sexual risk and opiate injection persists as a source of HIV transmission.
IeDEA collects HIV/AIDS data from seven international regional data centers, including four in Africa, and one each in the Asia-Pacific region, the Central/South America/Caribbean region, and North America. These regional data centers consolidate, curate and analyze data on care and treatment of HIV to evaluate the outcomes of people living with HIV/AIDS.
The program supports epidemiologists, data management specialists, bioinformaticians and statisticians to conduct research on collected clinical data. Sources of data include cohort studies, clinical trials networks, public and private clinics and hospitals, and private care providers. This type of data and resource pooling allows researchers to address unique and evolving research questions that individual cohorts are unable to answer.